Evidence for late stage compartmentalization of HIV-1 resistance mutations between lymph node and peripheral blood mononuclear cells.

doi:10.1097/00002030-200010200-00008

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Article

Evidence for late stage compartmentalization of HIV-1 resistance mutations between lymph node and peripheral blood mononuclear cells.

AIDS (London, England) - 20 Oct 2000

Haddad D N, Birch C, Middleton T, Dwyer D E, Cunningham A L, Saksena N K

Abstract excerpt

OBJECTIVE: To determine the overall distribution of drug-resistance mutations to nucleoside reverse transcriptase inhibitors of HIV strains recovered from the lymph nodes (LN) and peripheral blood mononuclear cell (PBMC) compartments of four HIV-infected patients receiving zidovudine and didanosine and to compare them with antiretroviral-naive patients. DESIGN: Molecular comparison of major and minor HIV-1 env...

Topics

Anti-HIV Agents
Didanosine
Drug Resistance, Microbial
Evolution, Molecular
Genes, env
Genes, pol
Genetic Variation
HIV Envelope Protein gp120
HIV Infections
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Lymph Nodes

Male

Mutation

Peptide Fragments

Time Factors

Zidovudine

Source

Open in PubMed

Identifiers

PMID: 11089615
DOI: 10.1097/00002030-200010200-00008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11089615-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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