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Article

Independent evolution of the env and pol genes of HIV-1 during zidovudine therapy.

AIDS (London, England) - 1 Sept 1996

Brown A J, Cleland A

Abstract excerpt

OBJECTIVE: To determine the effect that selection for antiviral resistance in the HIV-1 pol gene has on the level of variation and pattern of evolution in the V3 region of env. DESIGN: Proviral genomes obtained from two patients before, during and after the termination of zidovudine (ZDV) therapy...

Topics

Amino Acid Sequence
Anti-HIV Agents
Codon
Drug Resistance, Microbial
Genes, env
Genes, pol
Genetic Variation
HIV Infections
HIV-1
Humans
Likelihood Functions
Molecular Sequence Data
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phylogeny

Polymerase Chain Reaction

Proviruses

Recombination, Genetic

Sequence Analysis, DNA

Source

Identifiers

PMID: 8874622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8874622-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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