Article
Identification of functional domains in AMPD1 by mutational analysis.
Biochemical and biophysical research communications - 15 Dec 1994
Gross M, Morisaki H, Morisaki T, Holmes E W
Abstract excerpt
AMP deaminase (AMPD) is a complex allosteric enzyme encoded by a multigene family in higher eukaryotes. The amino terminus of each AMPD gene is unique, while the mild and carboxy termini have been highly conserved among all the AMPD genes. Mutational analyses of the AMPD1 gene demonstrate that the catalytic site and a regulatory site, likely an ATP binding site, are located in the highly conserved carboxy...
Topics
- AMP Deaminase
- Amino Acid Sequence
- Binding Sites
- Conserved Sequence
- DNA Mutational Analysis
- Genetic Variation
- Humans
- Kinetics
- Molecular Sequence Data
- Mutagenesis
- Polymerase Chain Reaction