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Article

Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis.

Arthritis and rheumatism - 1 Nov 2000

Moos V, Rudwaleit M, Herzog V, Höhlig K, Sieper J, Müller B

Abstract excerpt

OBJECTIVE: The majority of cytokines and growth factors known to be involved in cartilage metabolism are synthesized by the chondrocytes themselves. They are up-regulated in osteoarthritic (OA) cartilage, resulting in 2 opposite phenotypes, TNFalpha(high) and TNFalpha(low), that are characterized by an elevated number of tumor necrosis factor alpha (TNFalpha)-positive and interleukin-1beta (IL-1beta)-positive...

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Source

Identifiers

PMID: 11083263
DOI: 10.1002/1529-0131(200011)43:11<2417::AID-ANR7>3.0.CO;2-R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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