A single amino acid mutation (Ser180----Cys) determines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability.

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Article

A single amino acid mutation (Ser180----Cys) determines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability.

The Journal of biological chemistry - 25 Jan 1992

Faletto M B, Linko P, Goldstein J A

Abstract excerpt

Cytochrome P450g is polymorphic in the male rat. This polymorphism is characterized by a 20-40-fold difference in the hepatic content of P450g in the two phenotypes. Sequencing of cDNAs from high (+g) and low (-g) phenotype rats has shown that the low phenotype is due to a defective mRNA containi...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Western
Cloning, Molecular
Cysteine
Cytochrome P-450 Enzyme System
DNA
Enzyme Stability
Kinetics
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Phenotype

Plasmids

Polymorphism, Genetic

Rats

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 1730734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1730734-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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