Article
Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases.
Journal of neuropathology and experimental neurology - 1 Oct 2000
Perry A, Cai D X, Scheithauer B W, Swanson P E, Lohse C M, Newsham I F, Weaver A, Gutmann D H
Abstract excerpt
The molecular pathogenesis of meningiomas is poorly characterized. Loss of NF2 (merlin) expression has been reported in 30%-80% of all sporadic meningiomas. Recently, we found that loss of expression for a second Protein 4.1-family tumor suppressor. DAL-1, is also common. A biologically important role for progesterone receptor (PR) has also been proposed based on its reported inverse relationship with tumor...
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