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Article

Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.

Molecular pharmacology - 1 Jan 2007

Lima Walt F, Rose John B, Nichols Josh G, Wu Hongjiang, Migawa Michael T, Wyrzykiewicz Tadeusz K, Siwkowski Andrew M, Crooke Stanley T

Abstract excerpt

In a previous study, we demonstrated that the sugar conformation and helical geometry of the heteroduplex substrate at the catalytic site of human RNase H1 directs the selective recognition of the substrate by the enzyme (J Biol Chem 279: 36317-36326, 2004). In this study, we systematically intro...

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Identifiers

PMID: 17028158
DOI: 10.1124/mol.106.025015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17028158-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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