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Increased uracil misincorporation in lymphocytes from folate-deficient rats

1 Dec 2000

Abstract excerpt

The development of certain human cancers has been linked with inadequate intake of folates. The effects of folate deficiency in vivo on DNA stability (strand breakage, misincorporated uracil and oxidative base damage) in lymphocytes isolated from rats fed a diet deficient in folic acid was determined. Because the metabolic pathways of folate and other methyl donors are closely coupled, the effects of methionine...

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PMID: 11076664
DOI: 10.1054/bjoc.2000.1481

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