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Article

Folate supplementation differently affects uracil content in DNA in the mouse colon and liver.

The British journal of nutrition - 1 Mar 2011

Kim Kyong-Chol, Jang Hyeran, Sauer Julia, Zimmerly Ella M, Liu Zhenhua, Chanson Aurelie, Smith Donald E, Friso Simonetta, Choi Sang-Woon

Abstract excerpt

High folate intake may increase the risk of cancer, especially in the elderly. The present study examined the effects of ageing and dietary folate on uracil misincorporation into DNA, which has a mutagenic effect, in the mouse colon and liver. Old (18 months; n 42) and young (4 months; n 42) male C57BL/6 mice were pair-fed with four different amino acid-defined diets for 20 weeks: folate deplete (0 mg/kg diet);...

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Identifiers

PMID: 21251336
DOI: 10.1017/S0007114510004332
PMCID: PMC3259804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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