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Article

Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status

1 Dec 2000

Abstract excerpt

HMGI and HMGY are splicing variants of the HMGI(Y) gene and together with HMGI-C, belong to a family of DNA binding proteins involved in maintaining active chromatin conformation and in the regulation of gene transcription. The expression of the HMGI(Y) gene is maximal during embryonic development, declines in adult differentiated tissues and is reactivated in most transformed cells in vitro and in many human...

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PMID: 11076660
DOI: 10.1054/bjoc.2000.1494

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