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Article

High Mobility Group A1 Is a Molecular Target for MYCN in Human Neuroblastoma

15 Sept 2005

Abstract excerpt

High mobility group A1 (HMGA1) is an architectural transcription factor and a putative protoncogene. Deregulation of its expression has been shown in most human cancers. We have previously shown that the expression of the HMGA family members is deregulated in neuroblastoma cell lines and primary tumors. On retinoic acid (RA) treatment of MYCN-amplified neuroblastoma cell lines, HMGA1 decreases with a kinetics...

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Identifiers

PMID: 16166307
DOI: 10.1158/0008-5472.can-05-0607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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High Mobility Group A1 Is a Molecular Target for MYCN in Human NeuroblastomaPMID 16166307Read ↗

HMGA molecules in neuroblastic tumors.Semantic proximity Read ↗

Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation statusSemantic proximity Read ↗

Global MYCN Transcription Factor Binding Analysis in Neuroblastoma Reveals Association with Distinct E-Box Motifs and Regions of DNA HypermethylationSemantic proximity Read ↗

MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coinSemantic proximity Read ↗

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastomaSemantic proximity Read ↗

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4Semantic proximity Read ↗

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MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.Semantic proximity Read ↗

High Mobility Group A Proteins as Tumor MarkersSemantic proximity Read ↗

Epigenetic regulation of the neuroblastoma genes, Arid3b and MycnSemantic proximity Read ↗

Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma PatientsSemantic proximity Read ↗

Tumorigenic proteins upregulated in the MYCN-amplified IMR-32 human neuroblastoma cells promote proliferation and migrationSemantic proximity Read ↗

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