Article
Different innate ability of I/St and A/Sn mice to combat virulent Mycobacterium tuberculosis: phenotypes expressed in lung and extrapulmonary macrophages.
Infection and immunity - 1 Feb 2003
Majorov Konstantin B, Lyadova Irina V, Kondratieva Tatiana K, Eruslanov Eugeny B, Rubakova Elvira I, Orlova Marianna O, Mischenko Vladimir V, Apt Alexander S
Abstract excerpt
Mice of the I/St and A/Sn inbred strains display a severe and moderate course, respectively, of disease caused by Mycobacterium tuberculosis. Earlier, we showed that the response to mycobacterial antigens in I/St mice compared to that in A/Sn mice is shifted toward Th2-like reactivity and a higher proliferative activity and turnover of T cells. However, the physiologic basis for different expressions of...
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