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Article

The effects of rate variation on ancestral inference in the coalescent.

Genetics - 1 Nov 2000

Markovtsova L, Marjoram P, Tavaré S

Abstract excerpt

We describe a Markov chain Monte Carlo approach for assessing the role of site-to-site rate variation in the analysis of within-population samples of DNA sequences using the coalescent. Our framework is a Bayesian one. We discuss methods for assessing the goodness-of-fit of these models, as well as problems concerning the separate estimation of effective population size and mutation rate. Using a mitochondrial...

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Identifiers

PMID: 11063714
DOI: 10.1093/genetics/156.3.1427
PMCID: PMC1461332

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