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Article

Estimating effective population size and mutation rate from sequence data using Metropolis-Hastings sampling.

Genetics - 1 Aug 1995

Kuhner M K, Yamato J, Felsenstein J

Abstract excerpt

We present a new way to make a maximum likelihood estimate of the parameter 4N mu (effective population size times mutation rate per site, or theta) based on a population sample of molecular sequences. We use a Metropolis-Hastings Markov chain Monte Carlo method to sample genealogies in proportion to the product of their likelihood with respect to the data and their prior probability with respect to a coalescent...

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Identifiers

PMID: 7498781
DOI: 10.1093/genetics/140.4.1421
PMCID: PMC1206705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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