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Article

Estimating effective population size and mutation rate from sequence data using Metropolis-Hastings sampling.

Genetics - 1 Aug 1995

Kuhner M K, Yamato J, Felsenstein J

Abstract excerpt

We present a new way to make a maximum likelihood estimate of the parameter 4N mu (effective population size times mutation rate per site, or theta) based on a population sample of molecular sequences. We use a Metropolis-Hastings Markov chain Monte Carlo method to sample genealogies in proportion to the product of their likelihood with respect to the data and their prior probability with respect to a coalescent...

Topics

Base Sequence
DNA, Mitochondrial
Likelihood Functions
Markov Chains
Monte Carlo Method
Mutation
Phylogeny
Population Density
Software

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7498781
DOI: 10.1093/genetics/140.4.1421
PMCID: PMC1206705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7498781-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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