Article
Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 1996
Schröder A E, Greiner A, Seyfert C, Berek C
Abstract excerpt
In patients with rheumatoid arthritis the synovial membrane of the affected joint is infiltrated with lymphoid cells which may be arranged in structures resembling germinal centers. We have directly isolated such infiltrates to determine whether B-cell clones within them are selected and expanded in a process analogous to that which normally takes place in the germinal centers in secondary lymphoid organs. The...
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