Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2.

Abstract excerpt

Individuals with mutations in breast cancer susceptibility genes BRCA1 and BRCA2 have up to an 80% risk of developing breast cancer by the age of 70. Sequencing-based genetic tests are now available to identify mutation carriers in an effort to reduce mortality through prevention and early diagnosis. However, lack of a suitable functional assay hinders the risk assessment of more than 1,900 BRCA1 and BRCA2...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to BRCA2 Protein
• Share to Embryonic Stem Cells
• Share to Genes, BRCA1