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Article

Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity

23 Mar 2006

Abstract excerpt

Evolutionary sequence conservation is an accepted criterion to identify noncoding regulatory sequences. We have used a transposon-based transgenic assay in zebrafish to evaluate noncoding sequences at the zebrafish ret locus, conserved among teleosts, and at the human RET locus, conserved among mammals. Most teleost sequences directed ret-specific reporter gene expression, with many displaying overlapping...

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PMID: 16556802
DOI: 10.1126/science.1124070

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