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Article

A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Nov 2000

Kimura H, Gejyo F, Suzuki S, Takeda T, Miyazaki R, Yoshida H

Abstract excerpt

Patients undergoing hemodialysis have impaired metabolism of such sulfur-containing amino acids as cysteine (Cys) and homocysteine (Hcy), which may lead to accelerated atherosclerosis. Considering that Cys is mainly synthesized from Hcy, a common C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene may affect the serum total Cys (tCys) concentration, as well as total Hcy (tHcy) concentration,...

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidoreductases Acting on CH-NH Group Donors

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Source

Identifiers

PMID: 11054348
DOI: 10.1053/ajkd.2000.19085

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients.PMID 11054348Read ↗

The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.Semantic proximity Read ↗

Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.Semantic proximity Read ↗

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