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No significant correlation exists between core promoter mutations, viral replication, and liver damage in chronic hepatitis B infection.

Hepatology (Baltimore, Md.) - 1 Nov 2000

Chun Y K, Kim J Y, Woo H J, Oh S M, Kang I, Ha J, Kim S S

Abstract excerpt

Hepatitis B virus (HBV) core promoter mutants have been proposed to contribute to severe liver damage by increasing viral loads, but this has not yet been clearly shown. To examine the effects of core promoter mutants on viral load and liver damage, we first developed a polymerase chain reaction (PCR)-based semiquantitative HBV DNA detection method with a high sensitivity (able to detect as low as 10(3)...

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Identifiers

PMID: 11050069
DOI: 10.1053/jhep.2000.19623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No significant correlation exists between core promoter mutations, viral replication, and liver damage in chronic hepatitis B infection.PMID 11050069Read ↗

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