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Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis

1 Nov 2000

Abstract excerpt

The AML1 gene encodes a DNA-binding protein that contains the runt domain and is the most frequent target of translocations associated with human leukemias. Here, point mutations of the AML1 gene, V105ter (single-letter amino acid code) and R139G, (single-letter amino acid codes) were identified in 2 cases of myelodysplastic syndrome (MDS) by means of the reverse transcriptase-polymerase chain reaction...

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PMID: 11049997
DOI: 10.1182/blood.v96.9.3154

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Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesisPMID 11049997Read ↗

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