Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.

Blood - 15 Mar 1999

Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K, Ito Y

Abstract excerpt

The AML1 gene encoding the DNA-binding alpha-subunit in the Runt domain family of heterodimeric transcription factors has been noted for its frequent involvement in chromosomal translocations associated with leukemia. Using reverse transcriptase-polymerase chain reaction (RT-PCR) combined with no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to Dimerization
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Point Mutation

Share to Proto-Oncogene Proteins

Share to Receptor, Macrophage Colony-Stimulating Factor

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10068652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10068652-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.PMID 10068652Read ↗

Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesisSemantic proximity Read ↗

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.Semantic proximity Read ↗

A Novel Transcript Encoding an N-Terminally Truncated AML1/PEBP2αB Protein Interferes with Transactivation and Blocks Granulocytic Differentiation of 32Dcl3 Myeloid CellsSemantic proximity Read ↗

High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21.Semantic proximity Read ↗

AML-1 mutations outside the RUNT domain: description of two cases in myeloid malignancies.Semantic proximity Read ↗

Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain.Semantic proximity Read ↗

Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.Semantic proximity Read ↗

The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element.Semantic proximity Read ↗

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.Semantic proximity Read ↗

The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp.Semantic proximity Read ↗

Structural Analyses of DNA Recognition by the AML1/Runx-1 Runt Domain and Its Allosteric Control by CBFβSemantic proximity Read ↗

The Tyrosine Kinase Abl-Related Gene ARG Is Fused toETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal TranscriptsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.