Article
Rescued mice with Hb E transgene-developed red cell changes similar to human beta-thalassemia/HbE disease.
Annals of the New York Academy of Sciences - 1 Jan 2005
Wannasuphaphol Bundit, Kalpravidh Ruchaneekorn, Pattanapanyasat Kovit, Ioannau Panos, Kuypers Frans A, Fucharoen Suthat, Winichagoon Pranee
Abstract excerpt
A novel C57BL/6 transgenic murine model of HbE has been developed, and the heterotetrameric ((m)alpha2(h)beta(E)2) hemoglobin shows significant complementation of mild thalassemia phenotype in double heterozygous (beta(m+)beta(m-), beta(hE)) and homozygous knockout (beta(m-)beta(m-), beta(hE)) mice with 100% heterotetrameric hemoglobin. Lethal homozygous beta-thalassemic mice rescued by HbE transgenes mimic...
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