Article
HLA class II association with rheumatoid arthritis: facts and interpretations.
Human immunology - 1 Dec 2000
Zanelli E, Breedveld F C, de Vries R R
Abstract excerpt
We have reviewed the literature on the association of HLA class II with rheumatoid arthritis (RA). Strong linkage disequilibrium among DQB1, DQA1 and DRB1 alleles makes it difficult to evaluate the individual contribution of each locus. Nonetheless, there is a strong case for the role of DQB1*03 and *04 combined with DQA1*03 in susceptibility to severe RA while DQB1*0501 combined with DQA1*0101 and *0104 weakly...
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