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Article

Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2000

Donnadieu E, Cookson W O, Jouvin M H, Kinet J P

Abstract excerpt

Two variants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have been found associated with allergy. We have previously shown that the beta-chain plays at least two distinct amplifier functions. It amplifies Fc epsilon RI surface expression and signaling, resulting in an estimated 12- to 30-fold amplification of downstream events. To test the hypothesis that the...

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PMID: 11034399
DOI: 10.4049/jimmunol.165.7.3917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions.PMID 11034399Read ↗

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