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Article

Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.

Nature genetics - 1 Jun 1994

Shirakawa T, Li A, Dubowitz M, Dekker J W, Shaw A E, Faux J A, Ra C, Cookson W O, Hopkin J M

Abstract excerpt

The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60...

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Identifiers

PMID: 7920628
DOI: 10.1038/ng0694-125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.PMID 7920628Read ↗

Lack of association between atopy and the Ile181Leu variant of the beta-subunit of the high-affinity immunoglobulin E receptor.Semantic proximity Read ↗

Atopy phenotype in subjects with variants of the beta subunit of the high affinity IgE receptor.Semantic proximity Read ↗

Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions.Semantic proximity Read ↗

A genetic map of chromosome 11q, including the atopy locus.Semantic proximity Read ↗

LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.Semantic proximity Read ↗

Affected sib-pair and mutation analyses of the high affinity IgE receptor beta chain locus in Italian families with atopic asthmatic children.Semantic proximity Read ↗

Screening of the Fc epsilon RI-beta-gene in a Swiss population of asthmatic children: no association with E237G and identification of new sequence variations.Semantic proximity Read ↗

Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population.Semantic proximity Read ↗

Localisation of atopy and β subunit of high-affinity IgE receptor (Fc∈RI) on chromosome 11qSemantic proximity Read ↗

Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population.Semantic proximity Read ↗

Allelic association of gene markers on chromosome 11q in Italian families with atopy.Semantic proximity Read ↗

Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor.Semantic proximity Read ↗

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