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Article

Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.

Nature genetics - 1 Jun 1994

Shirakawa T, Li A, Dubowitz M, Dekker J W, Shaw A E, Faux J A, Ra C, Cookson W O, Hopkin J M

Abstract excerpt

The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60...

Topics

Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 11
DNA
Female
Genetic Variation
Humans
Hypersensitivity, Immediate
Male
Molecular Sequence Data
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Receptors, IgE

Source

Identifiers

PMID: 7920628
DOI: 10.1038/ng0694-125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7920628-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.PMID 7920628Read ↗

Lack of association between atopy and the Ile181Leu variant of the beta-subunit of the high-affinity immunoglobulin E receptor.Semantic proximity Read ↗

Atopy phenotype in subjects with variants of the beta subunit of the high affinity IgE receptor.Semantic proximity Read ↗

Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions.Semantic proximity Read ↗

A genetic map of chromosome 11q, including the atopy locus.Semantic proximity Read ↗

LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.Semantic proximity Read ↗

Affected sib-pair and mutation analyses of the high affinity IgE receptor beta chain locus in Italian families with atopic asthmatic children.Semantic proximity Read ↗

Screening of the Fc epsilon RI-beta-gene in a Swiss population of asthmatic children: no association with E237G and identification of new sequence variations.Semantic proximity Read ↗

Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population.Semantic proximity Read ↗

Localisation of atopy and β subunit of high-affinity IgE receptor (Fc∈RI) on chromosome 11qSemantic proximity Read ↗

Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population.Semantic proximity Read ↗

Allelic association of gene markers on chromosome 11q in Italian families with atopy.Semantic proximity Read ↗

Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor.Semantic proximity Read ↗

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