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Article

Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis.

Molecular and cellular biology - 1 Nov 2000

Rausa F M, Tan Y, Zhou H, Yoo K W, Stolz D B, Watkins S C, Franks R R, Unterman T G, Costa R H

Abstract excerpt

The winged helix transcription factor, hepatocyte nuclear factor-3beta (HNF-3beta), mediates the hepatocyte-specific transcription of numerous genes important for liver function. However, the in vivo role of HNF-3beta in regulating these genes remains unknown because homozygous null HNF3beta mouse embryos die in utero prior to liver formation. In order to examine the regulatory function of HNF-3beta, we created...

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Identifiers

PMID: 11027295
DOI: 10.1128/MCB.20.21.8264-8282.2000
PMCID: PMC86435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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