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Article

P53 null mice: damaging the hypothesis?

Mutation research - 18 Sept 2000

Sansom O J, Clarke A R

Abstract excerpt

P53 is extremely well characterised as a tumour suppressor gene, and many activities have been attributed to it which are consistent with this function. However, despite being the subject of intense study it still remains unclear precisely which of these functions is crucial to its in vivo role as a tumour suppressor gene. This is particularly true of its role in the induction of apoptosis. The original...

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Identifiers

PMID: 11024475
DOI: 10.1016/s0027-5107(00)00089-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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