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Article

NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.

Carcinogenesis - 1 Oct 2000

Lafuente M J, Casterad X, Trias M, Ascaso C, Molina R, Ballesta A, Zheng S, Wiencke J K, Lafuente A

Abstract excerpt

NAD(P)H:quinone oxidoreductase (NQO1) is a polymorphic enzyme involved in the detoxification of potentially mutagenic and carcinogenic quinones. The homozygous C609T NQO1 genotype resulting in loss of reductase activity is found in 2-20% of individuals. In the present study, the NQO1-dependent risk for sporadic colorectal cancer (CRC) was studied in 247 incident CRC cases and 296 hospital-based controls recruited...

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Source

Identifiers

PMID: 11023538
DOI: 10.1093/carcin/21.10.1813

Genes

NQO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.PMID 11023538Read ↗

NAD(P)H quinone oxidoreductase 1 codon 609 polymorphism and its association to colorectal cancer.Semantic proximity Read ↗

NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and colorectal cancer predisposition in the ethnic Kashmiri population.Semantic proximity Read ↗

Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.Semantic proximity Read ↗

No association between genetic polymorphisms in NAD(P)H oxidase p22phox and paraoxonase 1 and colorectal cancer risk.Semantic proximity Read ↗

Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

Association between NQO1 C609T polymorphism and colorectal cancer risk.Semantic proximity Read ↗

Contribution of NAD(P)H quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and risk of colorectal adenoma and colorectal cancer in Caucasians: a meta-analysis.Semantic proximity Read ↗

Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.Semantic proximity Read ↗

The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.Semantic proximity Read ↗

NQO1 and NFE2L2 polymorphisms, fruit and vegetable intake and smoking and the risk of colorectal adenomas in an endoscopy-based population.Semantic proximity Read ↗

The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.Semantic proximity Read ↗

Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk.Semantic proximity Read ↗

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