Article
NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
Carcinogenesis - 1 Oct 2000
Lafuente M J, Casterad X, Trias M, Ascaso C, Molina R, Ballesta A, Zheng S, Wiencke J K, Lafuente A
Abstract excerpt
NAD(P)H:quinone oxidoreductase (NQO1) is a polymorphic enzyme involved in the detoxification of potentially mutagenic and carcinogenic quinones. The homozygous C609T NQO1 genotype resulting in loss of reductase activity is found in 2-20% of individuals. In the present study, the NQO1-dependent ri...
Topics
- Age Factors
- Aged
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Genes, ras
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Mutation
- NAD(P)H Dehydrogenase (Quinone)
- Neoplasm Staging