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The origin of oncogenic mutations: where is the primary damage?

Carcinogenesis - 1 Oct 2000

Steen H B

Abstract excerpt

Cancer is generally believed to arise from a single cell which has become 'initiated' by mutation of a few crucial genes, caused by random 'hits' in its DNA, a 'hit' being an error in DNA replication or a reaction of the DNA with free radicals or other chemical species of exogenous or endogenous origin. It is not obvious how the epidemiological data on cancer incidence can be interpreted within the framework of...

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PMID: 11023532
DOI: 10.1093/carcin/21.10.1773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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