Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Envelope glycoprotein mutations mediate equine amplification and virulence of epizootic venezuelan equine encephalitis virus.

Journal of virology - 1 Jul 2005

Greene Ivorlyne P, Paessler Slobodan, Austgen Laura, Anishchenko Michael, Brault Aaron C, Bowen Richard A, Weaver Scott C

Abstract excerpt

Epidemics of Venezuelan equine encephalitis (VEE) result from high-titer equine viremia of IAB and IC subtype viruses that mediate increased mosquito transmission and spillover to humans. Previous genetic studies suggest that mutations in the E2 envelope glycoprotein allow relatively viremia-incompetent, enzootic subtype ID strains to adapt for equine replication, leading to VEE emergence. To test this hypothesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Horses

Share to Mutation

Share to Vero Cells

Share to Viral Envelope Proteins

Share to Viremia

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 15994807
DOI: 10.1128/JVI.79.14.9128-9133.2005
PMCID: PMC1168750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Envelope glycoprotein mutations mediate equine amplification and virulence of epizootic venezuelan equine encephalitis virus.PMID 15994807Read ↗

Venezuelan equine encephalitis.Semantic proximity Read ↗

Vector Infection Determinants of Venezuelan Equine Encephalitis Virus Reside within the E2 Envelope GlycoproteinSemantic proximity Read ↗

Virulence and viremia characteristics of 1992 epizootic subtype IC Venezuelan equine encephalitis viruses and closely related enzootic subtype ID strains.Semantic proximity Read ↗

Venezuelan equine encephalitis emergence: Enhanced vector infection from a single amino acid substitution in the envelope glycoproteinSemantic proximity Read ↗

Repeated emergence of epidemic/epizootic Venezuelan equine encephalitis from a single genotype of enzootic subtype ID virus.Semantic proximity Read ↗

Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation.Semantic proximity Read ↗

Positively Charged Amino Acid Substitutions in the E2 Envelope Glycoprotein Are Associated with the Emergence of Venezuelan Equine Encephalitis VirusSemantic proximity Read ↗

Association of Venezuelan equine encephalitis virus subtype IE with two equine epizootics in Mexico.Semantic proximity Read ↗

Variants of Venezuelan equine encephalitis virus that resist neutralization define a domain of the E2 glycoprotein.Semantic proximity Read ↗

Phylogenetic analysis of alphaviruses in the Venezuelan equine encephalitis complex and identification of the source of epizootic viruses.Semantic proximity Read ↗

RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergenceSemantic proximity Read ↗

Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.