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Article

Variants of Venezuelan equine encephalitis virus that resist neutralization define a domain of the E2 glycoprotein.

Virology - 1 Aug 1990

Johnson B J, Brubaker J R, Roehrig J T, Trent D W

Abstract excerpt

Stable neutralization (N) escape variants of Venezuelan equine encephalitis (VEE) virus were selected by anti-E2 glycoprotein monoclonal antibodies (MAbs) that neutralize viral infectivity, block viral hemagglutination, and passively protect mice. The nucleotide sequence of the E1, E2, and E3 genes of four variants revealed a clustering of single mutations in a domain spanning E2-182 to E2-207. The conformation...

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Identifiers

PMID: 1695412
DOI: 10.1016/0042-6822(90)90533-w

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Source receipt: pubmed, retrieved 7 Sept 2026.

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