Variants of Venezuelan equine encephalitis virus that resist neutralization define a domain of the E2 glycoprotein.

doi:10.1016/0042-6822(90)90533-w

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Article

Variants of Venezuelan equine encephalitis virus that resist neutralization define a domain of the E2 glycoprotein.

Virology - 1 Aug 1990

Johnson B J, Brubaker J R, Roehrig J T, Trent D W

Abstract excerpt

Stable neutralization (N) escape variants of Venezuelan equine encephalitis (VEE) virus were selected by anti-E2 glycoprotein monoclonal antibodies (MAbs) that neutralize viral infectivity, block viral hemagglutination, and passively protect mice. The nucleotide sequence of the E1, E2, and E3 genes of four variants revealed a clustering of single mutations in a domain spanning E2-182 to E2-207. The conformation...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antigens, Viral
Base Sequence
Encephalitis Virus, Venezuelan Equine
Epitopes
Genetic Variation
Molecular Sequence Data
Mutation
Neutralization Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Sequence Homology, Nucleic Acid

Software

Vero Cells

Viral Envelope Proteins

Virulence

Source

Open in PubMed

Identifiers

PMID: 1695412
DOI: 10.1016/0042-6822(90)90533-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1695412-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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