Article

CRKL but not CRKII Inhibits Erythropoiesis and Megakaryopoiesis of CML via Inactivating Raf/MEK/ERK/Elk-1 Pathway

2020-08-07

Abstract excerpt

<h4>Background: </h4> As members of the CT10 regulation of kinase (CRK) adaptor protein family, CRK-like (CRKL) and CRKII are involved in cell proliferation, survival, adhesion, migration and differentiation. However, the exact role and underlying mechanism of CRKL and CRKII in leukemic cell differentiation are still unknown. <h4>Methods: </h4>: Quantitative real-time qPCR (qRT-PCR) was used to detect the expressi...

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Literature Corpus work: 02587063-5313-5c61-91fa-2c88391ba0c7
DOI: 10.21203/rs.3.rs-53960/v1

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