Article
Resistance to antiretroviral drugs.
BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation - 1 Jan 1998
O'Brien W
Abstract excerpt
The goal of antiretroviral treatment is to reduce HIV replication and reduce the likelihood of developing mutant strains of HIV. HIV reproduces very rapidly and mutates often during the process of reverse transcription, and protease enzymes can lead to mutations later in the replication process. Patients using monotherapy rapidly develop resistance; current three-drug cocktails suppress replication much more...
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