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Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis in Human Neuronal Cells

15 Oct 2000

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) causes AIDS dementia complex (ADC) in certain infected individuals. Recent studies have suggested that patients with ADC have an increased incidence of neuronal apoptosis leading to neuronal dropout. Of note, a higher level of the HIV-1 accessory protein Vpr has been detected in the cerebrospinal fluid of AIDS patients with...

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PMID: 11000244
DOI: 10.1128/jvi.74.20.9717-9726.2000

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