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Article

Apoptosis Enhancement by the HIV-1 Nef Protein

1 Jan 2001

Abstract excerpt

The HIV-1 nef gene, essential for AIDS pathogenesis, encodes a 27-kDa protein (Nef) whose biochemical and biological functions are unclear. It has been suggested that Nef expression contributes to the T cell depletion observed during the disease by promoting their apoptosis. We report that in CD4(+) human lymphoblastoid cell lines transfected with the nef cDNA obtained from three different HIV-1 strains,...

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PMID: 11123279
DOI: 10.4049/jimmunol.166.1.81

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