Article
Method-dependent influence of certain polymorphisms in the factor V B-domain on the response to activated protein C.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2000
Siegert G, Kostka H, Gehrisch S, Schwarz T, Schellong S, Jaross W
Abstract excerpt
The factor V (FV) B-domain is extremely important to the cofactor function of native FV for activated protein C (APC) in the inactivation of factor VIII (FVIII). In a previous study, we found that in the B-domain coding portion of DNA, the polymorphisms at nucleotide positions 2391, 2663, 2684, and 2863 were associated. In the major allele, all bases are A (A allele) and those in the minor allele are G (G...
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