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Article

Frequency of polymorphisms in the B-domain of factor V gene in APC-resistant patients.

Thrombosis research - 15 Sept 2000

Kostka H, Siegert G, Schwarz T, Gehrisch S, Kuhlisch E, Schellong S, Jaross W

Abstract excerpt

In this study we investigated a group of patients in whom a resistance to APC (activated protein C) was found but no Leiden mutation existed in the presence of missense mutations in the first 1200 bp of the Exon 13 (B-domain) in the factor V (FV) gene. The determination of the APC response was performed using the Immunochrom(R) APC response Test Kit. The mutations were determined by temperature gradient gel...

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Share to Activated Protein C Resistance
Share to Exons
Share to Factor V

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Mutation, Missense

Share to Point Mutation

Share to Protein Structure, Tertiary

Share to Reagent Kits, Diagnostic

Source

Identifiers

PMID: 10974338
DOI: 10.1016/s0049-3848(00)00283-8

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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