Article
Direction of the reactivity of vanillyl-alcohol oxidase with 4-alkylphenols.
FEBS letters - 15 Sept 2000
van den Heuvel R H, Fraaije M W, van Berkel W J
Abstract excerpt
The covalent flavoprotein vanillyl-alcohol oxidase (VAO) predominantly converts short-chain 4-alkylphenols, like 4-ethylphenol, to (R)-1-(4'-hydroxyphenyl)alcohols and medium-chain 4-alkylphenols, like 4-butylphenol, to 1-(4'-hydroxyphenyl)alkenes. Crystallographic studies have indicated that the active site residue Asp170 is involved in determining the efficiency of substrate hydroxylation. To test this...
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