Article
Inversion of stereospecificity of vanillyl-alcohol oxidase.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2000
van Den Heuvel R H, Fraaije M W, Ferrer M, Mattevi A, van Berkel W J
Abstract excerpt
Vanillyl-alcohol oxidase (VAO) is the prototype of a newly recognized family of structurally related oxidoreductases sharing a conserved FAD-binding domain. The active site of VAO is formed by a cavity where the enzyme is able to catalyze many reactions with phenolic substrates. Among these reactions is the stereospecific hydroxylation of 4-ethylphenol-forming (R)-1-(4'-hydroxyphenyl)ethanol. During this...
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