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Article

Specificity of alcohol dehydrogenases for sulfoxides.

Biochemistry - 31 Mar 1998

Cho H, Plapp B V

Abstract excerpt

Sulfoxides inhibit horse liver alcohol dehydrogenase (EqADH) by binding to the enzyme-NADH complex. X-ray crystallography suggests that sulfoxides make a cation-pi interaction with the benzene ring of Phe-93 [Cho et al. (1997) Biochemistry 36, 382-389]. Structure-function relationships were exami...

Topics

Alanine
Alcohol Dehydrogenase
Amino Acid Substitution
Animals
Binding Sites
Enzyme Inhibitors
Horses
Humans
Isoenzymes
Models, Molecular
Mutation
Phenylalanine
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Substrate Specificity

Sulfoxides

Tryptophan

Source

Identifiers

PMID: 9521768
DOI: 10.1021/bi9727040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9521768-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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