Article
Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.
The Journal of biological chemistry - 30 Jul 2004
Trausch-Azar Julie S, Lingbeck Jody, Ciechanover Aaron, Schwartz Alan L
Abstract excerpt
Degradation of many short-lived cellular proteins such as the transcription factor MyoD occurs via the ubiquitin-proteasome pathway. MyoD, similar to many rapidly degraded regulatory factors, interacts with several high affinity binding partners, including members of the Id (inhibitors of DNA binding) family. Following transfection to HeLa cells, Id1 is localized to the nucleus and rapidly (t(1/2) approximately 1...
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