Article
Interpretation of genotypic HIV-1 resistance to darunavir and virological response: validation of available systems and of a new score.
Antiviral therapy - 1 Jan 2011
De Luca Andrea, Di Giambenedetto Simona, Maserati Renato, Gianotti Nicola, Narciso Pasquale, Antinori Andrea, Di Perri Giovanni, Prosperi Mattia C F, Baldanti Fausto, Micheli Valeria, Zazzi Maurizio, Perno Carlo F, Santoro Maria M
Abstract excerpt
BACKGROUND: There is not yet consensus on interpretation of genotypic HIV-1 resistance to darunavir (DRV). We validated existing rules and a newly derived score. METHODS: Protease inhibitor (PI)-failing patients starting a DRV/ritonavir-based regimen, with available baseline resistance genotypes, were extracted from three Italian databases. Virological response (VR) was analysed between 4 and 32 follow-up weeks,...
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