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Article

Bovine oocyte and embryo development following meiotic inhibition with butyrolactone I

1 Jan 2000

Abstract excerpt

In this study we have shown that butyrolactone I (BL-I), a potent inhibitor of cyclin-dependent kinases, inhibits meiotic resumption in bovine oocytes by blocking germinal vesicle breakdown in a dose-dependent manner. A concentration 100 microM blocked over 60% of oocytes, while 150 microM inhibited almost all oocytes compared to the control in which over 80% resumed meiosis. Following a second 24 hr culture...

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Identifiers

PMID: 10984421
DOI: 10.1002/1098-2795(200010)57:2<204::aid-mrd12>3.0.co;2-n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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