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Article

Effects of cilostamide and forskolin on the meiotic resumption and embryonic development of immature human oocytes

23 Jan 2008

Abstract excerpt

BACKGROUND: In an attempt to allow for acquisition of oocyte cytoplasmic maturation, PDE3 specific inhibitor, cilostamide and adenylate cyclase activator, forskolin were used to extend pre-maturation culture of immature human oocytes. METHODS: Cumulus-oocyte complexes retrieved from unstimulated ovaries were continuously cultured under 20 microM cilostamide or 50 microM forskolin, alone or in combination for 6,...

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PMID: 18216034
DOI: 10.1093/humrep/dem344

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