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Article

Effect of temporary nuclear arrest by Phosphodiesterase 3‐Inhibitor on morphological and functional aspects of in vitro matured mouse oocytes

28 Dec 2007

Abstract excerpt

The present study aimed to analyze detailed morphological and functional characteristics of mouse in vitro matured oocytes after a pre-maturation culture (PMC) by temporary nuclear arrest with the specific phosphodiesterase 3-inhibitor (PDE3-I) Cilostamide. In a first experiment the lowest effective dose of Cilostamide was determined. Cumulus-oocyte complexes (COCs), isolated from small antral follicles, were...

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PMID: 18163445
DOI: 10.1002/mrd.20851

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