Article
Role of tryptophan-1 in hemolytic and phospholipase C activities of Clostridium perfringens alpha-toxin.
Microbiology and immunology - 1 Jan 2000
Nagahama M, Mukai M, Ochi S, Sakurai J
Abstract excerpt
Replacement of the Trp-1 in Clostridium perfringens alpha-toxin with tyrosine caused no effect on hemolytic and phospholipase C (PLC) activities or on binding to the zinc ion, but that of the residue with alanine, glycine and histidine led to drastic decreases in these activities and a significant reduction in binding to the zinc ion. The hemolytic and PLC activities of W1H and W1A were significantly increased by...
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