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Article

Contribution of individual tryptophan residues to the structure and activity of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin.

European journal of biochemistry - 1 Nov 1996

Sekino-Suzuki N, Nakamura M, Mitsui K I, Ohno-Iwashita Y

Abstract excerpt

theta-Toxin (perfringolysin O), secreted by Clostridium perfringens, shares with other known thiol-activated toxins a conserved undecapeptide, ECTGLAWEWWR, located in the C-terminal region of the protein and containing the unique cysteine of the molecule. Single and double amino acid substitutions were created in the theta-toxin molecule to investigate the role of individual tryptophan residues in the lytic...

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Identifiers

PMID: 8944786
DOI: 10.1111/j.1432-1033.1996.00941.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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