Telomeres and disease

Abstract excerpt

The telomeres of most eukaryotes are characterized by guanine-rich repeats synthesized by the reverse transcriptase telomerase. Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other diseases including cancer. Differences in telomerase deficiency...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Telomeres, Telomerase, and Senescence