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Article

Recent advances in amyotrophic lateral sclerosis.

Current opinion in neurology - 1 Aug 2000

Al-Chalabi A, Leigh P N

Abstract excerpt

The mechanisms by which mutations of the SOD1 gene cause selective motor neuron death remain uncertain, although interest continues to focus on the role of peroxynitrite, altered peroxidase activity of mutant SOD1, changes in intracellular copper homeostasis, protein aggregation, and changes in the function of glutamate transporters leading to excitotoxicity. Neurofilaments and peripherin appear to play some part...

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Identifiers

PMID: 10970056
DOI: 10.1097/00019052-200008000-00006

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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