Amyotrophic lateral sclerosis.

doi:10.1186/1750-1172-4-3

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Article

Amyotrophic lateral sclerosis.

Orphanet journal of rare diseases - 3 Feb 2009

Wijesekera Lokesh C, Leigh P Nigel

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive muscular paralysis reflecting degeneration of motor neurones in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Incidence (average 1.89 per 100,000/year) and prevalence (average 5.2 per 100,000) are relatively uniform in Western countries, although foci of higher frequency occur in the...

Topics

Adult
Aged
Amyotrophic Lateral Sclerosis
DNA-Binding Proteins
Female
Humans
Male
Middle Aged
Motor Neurons
Mutation
Prognosis
Superoxide Dismutase
Superoxide Dismutase-1
Young Adult

Source

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Identifiers

PMID: 19192301
DOI: 10.1186/1750-1172-4-3
PMCID: PMC2656493

Genes

SOD1
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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